MANF Is Required for the Postnatal Expansion and Maintenance of Pancreatic β-Cell Mass in Mice
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چکیده
منابع مشابه
Postnatal Expansion of the Pancreatic β-Cell Mass Is Dependent on Survivin
OBJECTIVE Diabetes results from a deficiency of functional beta-cells due to both an increase in beta-cell death and an inhibition of beta-cell replication. The molecular mechanisms responsible for these effects in susceptible individuals are mostly unknown. The objective of this study was to determine whether a gene critical for cell division and cell survival in cancer cells, survivin, might ...
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In eukaryotes, vesicle trafficking is regulated by the small monomeric GTPases of the Rab protein family. Rab11, (a subfamily of the Ypt/Rab gene family) an evolutionarily conserved, ubiquitously expressed subfamily of small monomeric Rab GTPases, has been implicated in regulating vesicular trafficking through the recycling of endosomal compartment. In an earlier communication, we have shown th...
متن کاملSurvivin Is Required for Beta-Cell Mass Expansion in the Pancreatic Duct-Ligated Mouse Model
AIMS/HYPOTHESIS Pancreatic beta-cell mass expands through adulthood under certain conditions. The related molecular mechanisms are elusive. This study was designed to determine whether surviving (also known as Birc5), which is transiently expressed perinatally in islets, was required for beta-cell mass expansion in the pancreatic duct-ligated mouse model. METHODS Mice with beta cell-specific ...
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All forms of diabetes are characterized by a loss of functional β-cell mass, and strategies for expanding β-cell mass could have significant therapeutic benefit. We have recently identified the transcription factor Nkx6.1 as an essential maintenance factor of the functional β-cell state. In addition, Nkx6.1 has been proposed to control β-cell proliferation, but a role for Nkx6.1 in regulating β...
متن کاملPostnatal Expansion of the Pancreatic \(\beta\)-Cell Mass Is Dependent on Survivin
The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters. expansion of the pancreatic \(\beta\)-cell mass is dependent on survivin.
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ژورنال
عنوان ژورنال: Diabetes
سال: 2018
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db17-1149